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| Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p |
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| Author(s): Amos CI, Bali D, Thiel TJ, Anderson JP, Gourley I, Frazier ML, Lynch PM, Luchtefeld MA, Young A, McGarrity TJ, Seldin MF |
| Source: CANCER RESEARCH Volume: 57 Issue: 17 Pages: 3653-3656 Published: SEP 1 1997 |
| Times Cited: 59 References: 13 |
| Abstract: Peutz-Jeghers syndrome (PJS) was recently mapped in a single report to the telomeric region of chromosome 19p (A. Hemminki et al., Nat. Genet., 15: 87-90, 1997). Our studies confirm this location and provide further localization of the PJS locus. In the five families examined, there were no recombinants with the marker D19S886. The multipoint log odds score at D19S886 is 7.52, and me found no evidence for genetic heterogeneity. We also found that all carriers expressed the PJS phenotype and no noncarriers displayed PJS sequellae, indicating complete penetrance with no sporadic cases. |
| Document Type: Article |
| Language: English |
| Reprint Address: Amos, CI (reprint author), UNIV TEXAS, MD ANDERSON CANC CTR, DEPT EPIDEMIOL, BOX 189, 1515 HOLCOMBE BLVD, HOUSTON, TX 77030 USA |
Addresses:
1. DUKE UNIV, MED CTR, DEPT MED, DURHAM, NC 27710 USA
2. UNIV TEXAS, GRAD SCH BIOMED SCI, HOUSTON, TX 77030 USA
3. UNIV CALIF DAVIS, ROWE PROGRAM GENET, DEPT BIOL CHEM, DAVIS, CA 95616 USA
4. UNIV CALIF DAVIS, DEPT MED, DAVIS, CA 95616 USA
5. HOSP UNIV PENN, DEPT PATHOL & LAB MED, PHILADELPHIA, PA 19104 USA
6. UNIV TEXAS, MD ANDERSON CANC CTR, DEPT GASTROINTESTINAL ONCOL & DIGEST DIS, HOUSTON, TX 77030 USA
7. BLOGETT DIGEST DIS INST, BLODGETT MEM MED CTR, GRAND RAPIDS, MI 49503 USA
8. PENN STATE UNIV, MILTON S HERSHEY MED CTR, COLL MED, DIV GASTROENTEROL, DEPT MED, HERSHEY, PA 17033 USA |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: XU396 |
| ISSN: 0008-5472 |
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