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| Angiogenesis but not collateral growth is associated with ischemia after femoral artery occlusion |
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| Author(s): Ito WD, Arras M, Scholz D, Winkler B, Htun P, Schaper W |
| Source: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY Volume: 273 Issue: 3 Pages: H1255-H1265 Published: SEP 1997 |
| Times Cited: 156 References: 28 |
| Abstract: It remains unclear whether capillary sprouting (angiogenesis) and in situ growth of muscular collateral arteries share the same or different molecular mechanisms. To study the role of ischemia in these two forms of vascular proliferation, we measured tissue flows and maximum collateral conductances in hindlimbs of 22 rabbits previously subjected to either acute, 7-day, 21-day, or no femoral artery occlusion. After 1 wk of femoral artery occlusion, corkscrew collaterals were observed radiographically in the thigh. These collaterals showed histochemical evidence for active proliferation of endothelial and smooth muscle cells. Maximum collateral conductance increased sixfold in the Ist wk. Perfusion deficits, however were only observed in the distal adductor muscles (region of collateral reentry). In the lower leg, which suffered from a profound perfusion deficit, conductance increased in the absence of any visible collateral arteries but with evidence for capillary proliferation. This study therefore demonstrates that upon femoral artery occlusion angiogenesis occurs in regions of profound ischemia, whereas no direct correlation can be drawn between ischemia and collateral artery development. |
| Document Type: Article |
| Language: English |
| Reprint Address: Ito, WD (reprint author), Max Planck Inst Physiol & Clin Res, Dept Expt Cardiol, Benekestr 2, D-61231 Bad Nauheim, GERMANY |
Addresses:
1. Max Planck Inst Physiol & Clin Res, Dept Expt Cardiol, D-61231 Bad Nauheim, GERMANY |
| Publisher: AMER PHYSIOLOGICAL SOC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 |
| Subject Category: Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular Disease |
| IDS Number: XV709 |
| ISSN: 0363-6135 |
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