| | |  | | | | Record from Web of Science® | | | | | | |
| p73 is a human p53-related protein that can induce apoptosis |
|
|
| Author(s): Jost CA, Marin MC, Kaelin WG |
| Source: NATURE Volume: 389 Issue: 6647 Pages: 191-194 Published: SEP 11 1997 |
| Times Cited: 641 References: 25 |
| Abstract: The protein p53 is the most frequently mutated tumour suppressor to be identified so far in human cancers(1,2). The ability of p53 to inhibit cell growth is due, at least in part, to its ability to bind to specific DNA sequences and activate the transcription of target genes such as that encoding the cell-cycle inhibitor p21(Waf1/Cip1) (ref. 3), A gene has recently been identified that is predicted to encode a protein with significant amino-acid sequence similarity to p53 (ref, 4), In particular, each of the p53 amino-acid residues implicated in direct sequence-specific DNA binding is conserved in this protein(5). This gene, called p73, maps to the short arm of chromosome 1, and is found in a region that is frequently deleted in neuroblastomas(6). Here we show that p73 can, at least when overproduced, activate the transcription of p53-responsive genes and inhibit cell growth in a p53-like manner by inducing apoptosis (programmed cell death). |
| Document Type: Article |
| Language: English |
Addresses:
1. DANA FARBER CANC INST, BOSTON, MA 02115 USA
2. HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: XV757 |
| ISSN: 0028-0836 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |