| | |  | | | | Record from Web of Science® | | | | | | |
| Signalling through the neurotrophin receptor p75(NTR) |
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| Author(s): Dechant G, Barde YA |
| Source: CURRENT OPINION IN NEUROBIOLOGY Volume: 7 Issue: 3 Pages: 413-418 Published: JUN 1997 |
| Times Cited: 164 References: 58 |
| Abstract: Activation of specific tyrosine kinase receptors by neurotrophins accounts for the longest known biological actions of the neurotrophins, in particular the promotion of neuronal survival. However, recent studies have revealed that nerve growth factor, the neurotrophin regarded as best understood, also activates a signalling pathway by binding to the neurotrophin receptor p75(NTR). This receptor belongs to the tumor necrosis factor receptor family and lacks intrinsic catalytic activity. The p75(NTR) receptor binds all neurotrophins with nanomolar affinity; however, nerve growth factor seems to be uniquely able to activate it, causing the death of trkA-negative neurons during normal development. Thus, nerve growth factor prevents programmed cell death through its receptor TrkA, but promotes it by signalling through p75(NTR). |
| Document Type: Article |
| Language: English |
| Reprint Address: Dechant, G (reprint author), MAX PLANCK INST PSYCHIAT, DEPT NEUROBIOCHEM, KLOPFERSPITZ 18A, D-82152 MARTINSRIED, GERMANY |
| Publisher: CURRENT BIOLOGY LTD, 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB |
| Subject Category: Neurosciences |
| IDS Number: XW348 |
| ISSN: 0959-4388 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |