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| Implication of mitochondria in apoptosis |
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| Author(s): Petit PX, Zamzami N, Vayssiere JL, Mignotte B, Kroemer G, Castedo M |
| Source: MOLECULAR AND CELLULAR BIOCHEMISTRY Volume: 174 Issue: 1-2 Pages: 185-188 Published: SEP 1997 |
| Times Cited: 89 References: 16 |
| Abstract: The induction phase of programmed cell death (PCD) or apoptosis is characterized by an extreme heterogeneity of potential PCD-triggering signal transduction pathways. During the subsequent effector phase, the numerous PCD-inducing stimuli converge into a few stereotypical pathways and cells pass a 'point of no return', thus becoming irreversibly committed to death. Evidence is accumulating that cytoplasmic structures, including mitochondria, participate in the critical effector stage and that alterations usually considered to define apoptosis, as nuclear chromatolysis and cytolysis, have to be ascribed to the late degradation phase. We and others have recently shown that nuclear features of apoptosis are preceded by alterations in mitochondrial function and structure. The importance of these alterations for the apoptotic process and also the possible link between, these observations, the permeability transition pore and the programmed cell death, are discussed. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: Petit, PX (reprint author), CNRS, UPR 420, UNITE GENET MOL & BIOL DEV, EQUIPE APOPTOSE & IMMUNOL, 19 RUE GUY MOQUET, F-94801 VILLEJUIF, FRANCE |
Addresses:
1. CNRS, CTR GENET MOL, UPR 9061, GIF SUR YVETTE, FRANCE |
| Publisher: KLUWER ACADEMIC PUBL, SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS |
| Subject Category: Cell Biology |
| IDS Number: XW621 |
| ISSN: 0300-8177 |
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