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| LKLF: A transcriptional regulator of single-positive T cell quiescence and survival |
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| Author(s): Kuo CT, Veselits ML, Leiden JM |
| Source: SCIENCE Volume: 277 Issue: 5334 Pages: 1986-1990 Published: SEP 26 1997 |
| Times Cited: 213 References: 45 |
| Abstract: Mature single-positive (SP) T lymphocytes enter a ''resting'' state in which they are proliferatively quiescent and relatively resistant to apoptosis. The molecular mechanisms regulating this quiescent phenotype were unknown, Here it was found that the expression of a Kruppel-like zinc finger transcription factor, lung Kruppel-like factor (LKLF), is developmentally induced during the maturation of SP quiescent T cells and rapidly extinguished after SP T cell activation, LKLF-deficient T cells produced by gene targeting had a spontaneously activated phenotype and died in the spleen and lymph nodes from Fas ligand-induced apoptosis. Thus, LKLF is required to program the quiescent state of SP T cells and to maintain their viability in the peripheral lymphoid organs and blood. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV CHICAGO, DEPT MED, CHICAGO, IL 60637 USA
2. UNIV CHICAGO, DEPT PATHOL, CHICAGO, IL 60637 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: XX849 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |