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| Nitric oxide inhibits Fas-induced apoptosis |
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| Author(s): Mannick JB, Miao XQ, Stamler JS |
| Source: JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 272 Issue: 39 Pages: 24125-24128 Published: SEP 26 1997 |
| Times Cited: 237 References: 64 |
| Abstract: The Fas antigen (CD95, APO-1) is a transmembrane cell surface receptor that mediates apoptosis of many cell types when bound by Fas ligand or cross-linked by agonist antibody. The cellular factors regulating Fas-induced apoptosis have not been well defined. Here we show that basal nitric-oxide synthase (NOS) activity in human leukocytes inhibits Fas-induced apoptosis via a cGMP-independent mechanism. Further, NOS inhibits Fas-induced cleavage of poly(ADP-ribose) polymerase by members of the caspase family of cysteine proteases. These data suggest that Fas activity is under the control of the NO signaling pathway. NOS regulating the function of this member of the tumor necrosis factor receptor family suggests a new role for nitric oxide (or related molecules) in the human immune response. |
| Document Type: Article |
| Language: English |
| Reprint Address: Mannick, JB (reprint author), DANA FARBER CANC INST, DIV INFECT DIS, JFB 422, 44 BINNEY ST, BOSTON, MA 02115 USA |
Addresses:
1. DUKE UNIV, MED CTR, HOWARD HUGHES MED INST, DEPT MED, DIV RESP, DURHAM, NC 27710 USA
2. DUKE UNIV, MED CTR, HOWARD HUGHES MED INST, DEPT MED, DIV CARDIOVASC MED, DURHAM, NC 27710 USA
3. DUKE UNIV, MED CTR, DEPT CELL BIOL, DURHAM, NC 27710 USA |
| Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: XY515 |
| ISSN: 0021-9258 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |