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| Antagonism of central melanocortin receptors in vitro and in vivo by Agouti-related protein |
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| Author(s): Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen YR, Gantz I, Barsh GS |
| Source: SCIENCE Volume: 278 Issue: 5335 Pages: 135-138 Published: OCT 3 1997 |
| Times Cited: 851 References: 37 |
| Abstract: Expression of Agouti protein is normally limited to the skin where it affects pigmentation, but ubiquitous expression causes obesity. An expressed sequence tag was identified that encodes Agouti-related protein, whose RNA is normally expressed in the hypothalamus and whose levels were increased eightfold in ob/ob mice. Recombinant Agoutirelated protein was a potent, selective antagonist of Mc3r and Mc4r, melanocortin receptor subtypes implicated in weight regulation, Ubiquitous expression of human AGRP complementary DNA in transgenic mice caused obesity without altering pigmentation, Thus, Agouti-related protein is a neuropeptide implicated in the normal control of body weight downstream of leptin signaling. |
| Document Type: Article |
| Language: English |
Addresses:
1. STANFORD UNIV, SCH MED, BECKMAN CTR B271A, DEPT PEDIAT, STANFORD, CA 94305 USA
2. STANFORD UNIV, SCH MED, DEPT GENET, STANFORD, CA 94305 USA
3. STANFORD UNIV, SCH MED, HOWARD HUGHES MED INST, STANFORD, CA 94305 USA
4. UNIV MICHIGAN, SCH MED, DEPT SURG, ANN ARBOR, MI 48109 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: XZ124 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |