| | |  | | | | Record from Web of Science® | | | | | | |
| E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis |
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| Author(s): Vos CBJ, CletonJansen AM, Berx G, deLeeuw WJF, terHaar NT, vanRoy F, Cornelisse CJ, Peterse JL, vandeVijver MJ |
| Source: BRITISH JOURNAL OF CANCER Volume: 76 Issue: 9 Pages: 1131-1133 Published: NOV 1997 |
| Times Cited: 138 References: 12 |
| Abstract: In breast cancer, inactivating point mutations in the E-cadherin gene are frequently found in invasive lobular carcinoma (ILC) but never in invasive ductal carcinoma (IDC). Lobular carcinoma in situ (LCIS) adjacent to ILC has previously been shown to lack E-cadherin expression, but whether LCIS without adjacent invasive carcinoma also lacks E-cadherin expression and whether the gene mutations present in ILC are already present in LCIS is not known. We report here that E-cadherin expression is absent in six cases of LCIS and present in 150 cases of ductal carcinoma in situ (DCIS), both without an adjacent invasive component. Furthermore, using mutation analysis, we could demonstrate the presence of the same truncating mutations and loss of heterozygosity (LOH) of the wild-type E-cadherin in the LCIS component and in the adjacent ILC. Our results indicate that E-cadherin is a very early target gene in lobular breast carcinogenesis and plays a tumour-suppressive role, additional to the previously suggested invasion-suppressive role. |
| Document Type: Article |
| Language: English |
| Reprint Address: Vos, CBJ (reprint author), LEIDEN UNIV, MED CTR, DEPT PATHOL, POB 9600, NL-2300 RC LEIDEN, NETHERLANDS |
Addresses:
1. STATE UNIV GHENT, DEPT MOL BIOL, CELLULAR & MOL BIOL LAB, B-9000 GHENT, BELGIUM
2. VIB, GHENT, BELGIUM
3. NETHERLANDS CANC INST, DEPT PATHOL, NL-1066 CX AMSTERDAM, NETHERLANDS |
| Publisher: CHURCHILL LIVINGSTONE, JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND |
| Subject Category: Oncology |
| IDS Number: YD134 |
| ISSN: 0007-0920 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |