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| Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains |
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| Author(s): Markel P, Shu P, Ebeling C, Carlson GA, Nagle DL, Smutko JS, Moore KJ |
| Source: NATURE GENETICS Volume: 17 Issue: 3 Pages: 280-284 Published: NOV 1997 |
| Times Cited: 197 References: 15 |
| Abstract: Congenic breeding strategies are becoming increasingly important as a greater number of complex trait linkages are identified. Traditionally, the development od a congenic strain Ras been a time-consuming endeavour, requiring ten generations of backcrosses. The recent advent of a dense molecular genetic map of the mouse permits methods that can reduce the time needed for congenic-strain production by 18-24 months. We present a theoretical evaluation of marker-assisted congenic production and provide the empirical data that support it. We present this 'speed congenic' method in a user-friendly manner to encourage other investigators to pursue this or similar methods of congenic production. |
| Document Type: Article |
| Language: English |
Addresses:
1. MILLENNIUM PHARMACEUT, CAMBRIDGE, MA 02139 USA
2. MCLAUGHLIN RES INST, GREAT FALLS, MT 59405 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: YD667 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |