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| Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta 1 levels |
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| Author(s): Ashcroft GS, Dodsworth J, vanBoxtel E, Tarnuzzer RW, Horan MA, Schultz GS, Ferguson MWJ |
| Source: NATURE MEDICINE Volume: 3 Issue: 11 Pages: 1209-1215 Published: NOV 1997 |
| Times Cited: 198 References: 22 |
| Abstract: The cellular and molecular mechanisms underlying the effects of aging on human cutaneous wound healing are poorly understood, and the possible role of reproductive hormones in this process has never been investigated. We report that aging in healthy females was associated with a reduced rate of cutaneous wound healing, but an improved quality of scarring both microscopically and macroscopically, and with reduced levels of transforming growth factor-beta 1 (TCF-beta 1) immunostaining and steady-state mRNA in the wound. These age-related changes were reversed by the systemic administration of hormone replacement therapy (HRT). Moreover, ovariectomized young female rodents exhibited a marked delay in repair of acute incisional wounds, which was reversed by the topical application of estrogen. The cellular mechanism underlying these changes appears to Involve an estrogen-induced increase in latent TCF-beta 1 secretion by dermal fibroblasts. These results suggest that both the rate and quality of wound healing depend on reproductive hormone levels. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV MANCHESTER, SCH BIOL SCI, CELLS IMMUNOL & DEV DIV, MANCHESTER M13 9PT, LANCS ENGLAND
2. UNIV S MANCHESTER HOSP, DEPT GERIATR MED, MANCHESTER M20 2LR, LANCS ENGLAND
3. UNIV FLORIDA, DEPT OBSTET & GYNECOL, GAINESVILLE, FL 32610 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: YD896 |
| ISSN: 1078-8956 |
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