| | |  | | | | Record from Web of Science® | | | | | | |
| The HtrA family of serine proteases |
|
|
| Author(s): Pallen MJ, Wren BW |
| Source: MOLECULAR MICROBIOLOGY Volume: 26 Issue: 2 Pages: 209-221 Published: OCT 1997 |
| Times Cited: 204 References: 72 |
| Abstract: HtrA, also known as DegP and probably identical to the Do protease, is a heat shock-induced serine protease that is active in the periplasm of Escherichia coli, Homologues of HtrA have been described in a wide range of bacteria and in eukaryotes. Its chief role is to degrade misfolded proteins in the periplasm, Substrate recognition probably involves the recently described PDZ domains in the C-terminal half of HtrA and, we suspect, has much in common with the substrate recognition system of the tail-specific protease, Prc (which also possesses a PDZ domain). The expression of htrA is regulated by a complex set of signal transduction pathways, which includes an alternative sigma factor, RpoE, an anti-sigma factor, RseA, a two-component regulatory system, CpxRA, and two phosphoprotein phosphatases, PrpA and PrpB. Mutations in the htrA genes of Salmonella, Brucella and Yersinia cause decreased survival in mice and/or macrophages, and htrA mutants can act as vaccines, as cloning hosts and as carriers of heterologous antigens. |
| Document Type: Review |
| Language: English |
| Reprint Address: Pallen, MJ (reprint author), ST BARTHOLOMEWS & ROYAL LONDON SCH MED & DENT, DEPT MED MICROBIOL, MICROBIAL PATHOGENIC RES GRP, LONDON EC1A 7BE, ENGLAND |
| Publisher: BLACKWELL SCIENCE LTD, P O BOX 88, OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0NE |
| Subject Category: Biochemistry & Molecular Biology; Microbiology |
| IDS Number: YF447 |
| ISSN: 0950-382X |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |