| | |  | | | | Record from Web of Science® | | | | | | |
| Requirement for the CD95 receptor-ligand pathway in c-myc-induced apoptosis |
|
|
| Author(s): Hueber AO, Zornig M, Lyon D, Suda T, Nagata S, Evan GI |
| Source: SCIENCE Volume: 278 Issue: 5341 Pages: 1305-1309 Published: NOV 14 1997 |
| Times Cited: 273 References: 35 |
| Abstract: Induction of apoptosis by oncogenes like c-myc may be important in restraining the emergence of neoplasia, However, the mechanism by which c-myc induces apoptosis is unknown. CD95 (also termed Fas or APO-I) is a cell surface transmembrane receptor of the tumor necrosis factor receptor family that activates an intrinsic apoptotic suicide program in cells upon binding either its ligand CD95L or antibody, c-myc-induced apoptosis was shown to require interaction on the cell surface between CD95 and its ligand. c-Myc acts downstream of the CD95 receptor by sensitizing cells to the CD95 death signal. Moreover, IGF-I signaling and Bcl-2 suppress c-myc-induced apoptosis by also acting downstream of CD95, These findings link two apoptotic pathways previously thought to be independent and establish the dependency of Myc on CD95 signaling for its killing activity. |
| Document Type: Article |
| Language: English |
Addresses:
1. IMPERIAL CANC RES FUND, LONDON WC2A 3PX, ENGLAND
2. OSAKA UNIV, SCH MED, DEPT GENET, SUITA, OSAKA 565 JAPAN |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: YG043 |
| ISSN: 0036-8075 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |