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| Oral squamous cell carcinoma after allogeneic bone marrow transplantation for Fanconi anaemia |
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| Author(s): Millen FJ, Rainey MG, Hows JM, Burton PA, Irvine GH, Swirsky D |
| Source: BRITISH JOURNAL OF HAEMATOLOGY Volume: 99 Issue: 2 Pages: 410-414 Published: NOV 1997 |
| Times Cited: 28 References: 30 |
| Abstract: We report a case of oral squamous cell carcinoma (SCC) originating in the buccal mucosa of an 18-year-old female patient with chronic graft-versus-host disease (GVHD) 9 years after HLA-identical sibling bone marrow transplantation (BMT) for Fanconi anaemia (FA). The case highlights the problems of malignant change in FA and also the increased risk of second malignancy after BMT. The literature is reviewed with regard to previous cases and the possible aetiology of tumour formation. A high index of suspicion to any epithelial lesion in FA is appropriate so that early diagnosis may lead to improved prognosis. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV BRISTOL, SOUTHMEAD HOSP, DIV TRANSPLANTAT SCI, BRISTOL BS10 5NB, AVON ENGLAND
2. SOUTHMEAD GEN HOSP, NHS TRUST, BRISTOL, AVON ENGLAND
3. ROYAL POSTGRAD MED SCH, DEPT HAEMATOL, LONDON W12 0HS, ENGLAND |
| Publisher: BLACKWELL SCIENCE LTD, P O BOX 88, OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0NE |
| Subject Category: Hematology |
| IDS Number: YG535 |
| ISSN: 0007-1048 |
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