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| Epidermal growth factor receptor expression is associated with rapid tumor cell proliferation in renal cell carcinoma |
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| Author(s): Moch H, Sauter G, Buchholz N, Gasser TC, Bubendorf L, Waldman FM, Mihatsch MJ |
| Source: HUMAN PATHOLOGY Volume: 28 Issue: 11 Pages: 1255-1259 Published: NOV 1997 |
| Times Cited: 47 References: 36 |
| Abstract: Epidermal growth factor receptor (EGF-r) expression and tumor cell proliferation rate have been proposed as potential prognostic parameters in renal cell carcinoma (RCC). In this study, immunohistochemical stains using antibodies to EGF-r and the cell proliferation marker Ki-67 (MIB-1) were used to study the relationship between EGF-r expression, tumor cell proliferation, and prognosis in 50 nonpapillary RCC extending beyond the renal capsule (pT3). A high Ki-67 labeling index (LI) was associated with poor patient prognosis (P <.05). Thirty-eight cases (76%) expressed strong cell membrane immunoreactivity for EGF-r. There was a tendency toward a shortened survival for EGF-r-positive tumors (P =.08). Tumor growth fraction (Ki-67 LI) was significantly higher in EGF-r-positive tumors than in EGF-r-negative tumors (P <.05), suggesting that rapid tumor proliferation might be responsible for the poor prognosis associated with EGF-r-positive RCC. Copyright (C) 1997 by W.B. Saunders Company. |
| Document Type: Article |
| Language: English |
| Reprint Address: Moch, H (reprint author), UNIV BASEL, INST PATHOL, SCHONBEINSTR 40, CH-4003 BASEL, SWITZERLAND |
Addresses:
1. UNIV BASEL, DEPT UROL, CH-4003 BASEL, SWITZERLAND
2. UNIV CALIF SAN FRANCISCO, DEPT LAB MED, DIV MOL CYTOMETRY, SAN FRANCISCO, CA 94143 USA |
| Publisher: W B SAUNDERS CO, INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 |
| Subject Category: Pathology |
| IDS Number: YH034 |
| ISSN: 0046-8177 |
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