| | |  | | | | Record from Web of Science® | | | | | | |
| Signaling through scaffold, anchoring, and adaptor proteins |
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| Author(s): Pawson T, Scott JD |
| Source: SCIENCE Volume: 278 Issue: 5346 Pages: 2075-2080 Published: DEC 19 1997 |
| Times Cited: 1,411 References: 103 |
| Abstract: The process by which extracellular signals are relayed from the plasma membrane to specific intracellular sites is an essential facet of cellular regulation. Many signaling pathways do so by altering the phosphorylation state of tyrosine, serine, or threonine residues of target proteins. Recently, it has become apparent that regulatory mechanisms exist to influence where and when protein kinases and phosphatases are activated in the cell. The role of scaffold, anchoring, and adaptor proteins that contribute to the specificity of signal transduction events by recruiting active enzymes into signaling networks or by placing enzymes close to their substrates is discussed. |
| Document Type: Review |
| Language: English |
| Reprint Address: Pawson, T (reprint author), MT SINAI HOSP, SAMUEL LUNENFELD RES INST, 600 UNIV AVE, TORONTO, ON M5G 1X5 CANADA |
Addresses:
1. HOWARD HUGHES MED INST, VOLLUM INST, PORTLAND, OR 97201 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: YM235 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |