| | |  | | | | Record from Web of Science® | | | | | | |
| Emergent properties of networks of biological signaling pathways |
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| Author(s): Bhalla US, Iyengar R |
| Source: SCIENCE Volume: 283 Issue: 5400 Pages: 381-387 Published: JAN 15 1999 |
| Times Cited: 619 References: 57 |
| Abstract: Many distinct signaling pathways allow the cell to receive, process, and respond to information. Often, components of different pathways interact, resulting in signaling networks. Biochemical signaling networks were constructed with experimentally obtained constants and analyzed by computational methods to understand their role in complex biological processes. These ner:works exhibit emergent properties such as integration of signals across multiple time scales, generation of distinct outputs depending on input strength and duration, and self-sustaining feedback Loops. Feedback can result in bistable behavior with discrete steady-state activities, well-defined input thresholds for transition between states and prolonged signal output, and signal modulation in response to transient stimuli. These properties of signaling networks raise the possibility that information for "learned behavior" of biological systems may be stored within intracellular biochemical reactions that comprise signaling pathways. |
| Document Type: Article |
| Language: English |
| Reprint Address: Iyengar, R (reprint author), CUNY Mt Sinai Sch Med, Dept Pharmacol, Box 1215, New York, NY 10029 USA |
Addresses:
1. CUNY Mt Sinai Sch Med, Dept Pharmacol, New York, NY 10029 USA
2. Natl Ctr Biol Sci, Bangalore 560012, Karnataka India |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 157MV |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |