| | |  | | | | Record from Web of Science® | | | | | | |
| Notch signaling: Cell fate control and signal integration in development |
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| Author(s): Artavanis-Tsakonas S, Rand MD, Lake RJ |
| Source: SCIENCE Volume: 284 Issue: 5415 Pages: 770-776 Published: APR 30 1999 |
| Times Cited: 2,142 References: 109 |
| Abstract: Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis. |
| Document Type: Review |
| Language: English |
| Reprint Address: Artavanis-Tsakonas, S (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Cell Biol,Canc Ctr, Bldg 149,13th St, Charlestown, MA 02129 USA |
Addresses:
1. Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Cell Biol,Canc Ctr, Charlestown, MA 02129 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 192AW |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |