| | |  | | | | Record from Web of Science® | | | | | | |
| Smaug, a novel RNA-binding protein that operates a translational switch in Drosophila |
|
|
| Author(s): Dahanukar A, Walker JA, Wharton RP |
| Source: MOLECULAR CELL Volume: 4 Issue: 2 Pages: 209-218 Published: AUG 1999 |
| Times Cited: 102 References: 46 |
| Abstract: During Drosophila embryogenesis, a gradient of Nanos protein emanating from the posterior pole organizes abdominal segmentation. This gradient arises from translational regulation of nanos mRNA, which is activated in the specialized cytoplasm at the posterior pole of the embryo and repressed elsewhere. Previously, we have defined cis-acting elements in the mRNA that mediate this translational switch. In this report, we identify a factor named Smaug that binds to these elements and represses translation in the bulk cytoplasm. Smaug interacts genetically and biochemically with Oskar, a key component of the pole plasm for activation of nanos mRNA and specification of the germline precursors. These observations suggest that Smaug operates a translational switch that governs the distribution of Nanos protein. |
| Document Type: Article |
| Language: English |
| Reprint Address: Wharton, RP (reprint author), Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Genet, Durham, NC 27710 USA |
Addresses:
1. Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Genet, Durham, NC 27710 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 232UE |
| ISSN: 1097-2765 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |