| | |  | | | | Record from Web of Science® | | | | | | |
| Protein phosphatase 2A: Variety of forms and diversity of functions |
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| Author(s): Lechward K, Awotunde OS, Swiatek W, Muszynska G |
| Source: ACTA BIOCHIMICA POLONICA Volume: 48 Issue: 4 Pages: 921-933 Published: 2001 |
| Times Cited: 73 References: 68 |
| Abstract: Protein phosphatase 2A (PP2A) comprises a diverse family of phosphoserine- and phosphothreonine-specific phosphatases present in all eukaryotic cells. All forms of PP2A contain a catalytic subunit (PP2Ac) which forms a stable complex with the structural subunit PR65/A. The heterodimer PP2Ac-PR65/A associates with regulatory proteins, termed variable subunits, in order to form trimeric holoenzymes attributed with distinct substrate specificity and targeted to different subcellular compartments. PP2Ac activity can be modulated by reversible phosphorylation on Tyr(307) an methylation on C-terminal Leu(309). Studies on PP2A have shown that this enzyme may be implicated in the regulation of metabolism, transcription, RNA splicing, translation, differentiation, cell cycle, oncogenic transformation and signal transduction. |
| Document Type: Review |
| Language: English |
| Reprint Address: Muszynska, G (reprint author), Polish Acad Sci, Inst Biochem & Biophys, A Pawinskiego 5A, PL-02106 Warsaw, Poland |
Addresses:
1. Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland
2. Med Univ Gdansk, Intercollegiate Fac Biotechnol, Cell & Mol Signaling Lab, Gdansk, Poland |
| Publisher: ACTA BIOCHIMICA POLONICA, PASTEURA 3, 02-093 WARSAW, POLAND |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: 507WG |
| ISSN: 0001-527X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |