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| Transient receptor potential channels regulate myogenic tone of resistance arteries |
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| Author(s): Welsh DG, Morielli AD, Nelson MT, Brayden JE |
| Source: CIRCULATION RESEARCH Volume: 90 Issue: 3 Pages: 248-250 Published: FEB 22 2002 |
| Times Cited: 166 References: 17 |
| Abstract: Elevation of intravascular pressure causes depolarization and constriction (myogenic tone) of small arteries and arterioles, and this response is a key element in blood flow regulation. However, the nature of pressure-induced depolarization has remained elusive. In the present study, we provide evidence that a transient receptor potential channel (TRPC6) homologue has a major role in this depolarizing response to pressure. Antisense oligodeoxynucleotides to TRPC6 decreased TRPC6 protein expression and greatly attenuated arterial smooth muscle depolarization and constriction caused by elevated pressure in intact cerebral arteries. Suppressing the expression of this channel protein also reduced the current density of a major cation current in resistance artery smooth muscle cells. We propose that TRPC6 channels play an essential role in regulation of myogenic tone. |
| Document Type: Article |
| Language: English |
| Reprint Address: Brayden, JE (reprint author), Univ Vermont, Dept Pharmacol, Coll Med, Given Med Bldg, Burlington, VT 05405 USA |
Addresses:
1. Univ Vermont, Dept Pharmacol, Coll Med, Burlington, VT 05405 USA |
| Publisher: LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA |
| Subject Category: Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular Disease |
| IDS Number: 524TZ |
| ISSN: 0009-7330 |
| DOI: 10.1161/hh0302.105662 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |