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| Nuclear actin and actin-related proteins in chromatin remodeling |
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| Author(s): Olave IA, Reck-Peterson SL, Crabtree GR |
| Source: ANNUAL REVIEW OF BIOCHEMISTRY Volume: 71 Pages: 755-781 Published: 2002 |
| Times Cited: 201 References: 150 |
| Abstract: The existence and function of actin in the nucleus has been hotly debated for forty years. Recently, beta-actin was found to be a component of mammalian SWI/SNF-like BAF chromatin remodeling complexes and still more recently other SWI/SNF-related chromatin remodeling complexes in yeast, flies, and man. Although the function of actin in these chromatin remodeling complexes is only starting to be explored, the fact that actin is one of the most regulated proteins in the cell suggests that control of nuclear actin may be a critical regulatory point in the control of chromatin remodeling. Actin rapidly shuttles between the nucleus and the cytoplasm offering additional sites and modes of regulation. In addition, actin-related proteins (Arps) are also components of these chromatin remodeling complexes and have been implicated in transcriptional control in yeast. The observation that the BAF chromatin remodeling complex in which actin was originally identified, is also a human tumor suppressor complex necessary for the actions of the retinoblastoma protein indicates that the study of nuclear actin is likely to contribute to understanding cell growth control. |
| Document Type: Review |
| Language: English |
| Reprint Address: Olave, IA (reprint author), Stanford Univ, Howard Hughes Med Inst, Dept Dev Biol, Stanford, CA 94305 USA |
Addresses:
1. Stanford Univ, Howard Hughes Med Inst, Dept Dev Biol, Stanford, CA 94305 USA
2. Stanford Univ, Howard Hughes Med Inst, Dept Pathol, Stanford, CA 94305 USA |
| Publisher: ANNUAL REVIEWS, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: 582MJ |
| ISSN: 0066-4154 |
| DOI: 10.1146/annurev.biochem.71.110601.135507 |
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