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Computational systems biology
Author(s): Kitano H
Source: NATURE    Volume: 420    Issue: 6912    Pages: 206-210    Published: NOV 14 2002  
Times Cited: 430     References: 69     
Abstract: To understand complex biological systems requires the integration of experimental and computational research - in other words a systems biology approach. Computational biology, through pragmatic modelling and theoretical exploration, provides a powerful foundation from which to address critical scientific questions head-on. The reviews in this Insight cover many different aspects of this energetic field, although all, in one way or another, illuminate the functioning of modular circuits, including their robustness, design and manipulation. Computational systems biology addresses questions fundamental to our understanding of life, yet progress here will lead to practical innovations in medicine, drug discovery and engineering.
Document Type: Editorial Material
Language: English
Reprint Address: Kitano, H (reprint author), Sony Comp Sci Labs Inc, 3-14-13 Higashi Gotanda, Tokyo 1410022, Japan
Addresses:
1. Sony Comp Sci Labs Inc, Tokyo 1410022, Japan
2. Japan Sci & Technol Corp, ERATO, Kitano Symbiot Syst Project, Tokyo 1500001, Japan
3. Syst Biol Inst, Tokyo 1500001, Japan
4. Keio Univ, Sch Fundamental Sci & Technol, Kohoku Ku, Kanagawa 2238522, Japan
5. CALTECH, Pasadena, CA 91125 USA
Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Subject Category: Multidisciplinary Sciences
IDS Number: 614QM
ISSN: 0028-0836
DOI: 10.1038/nature01254
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