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| Actin in the nucleus: what form and what for? |
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| Author(s): Pederson T, Aebi U |
| Source: JOURNAL OF STRUCTURAL BIOLOGY Volume: 140 Issue: 1-3 Pages: 3-9 Published: OCT-DEC 2002 |
| Times Cited: 87 References: 46 |
| Abstract: Actin is an abundant protein in most nonmuscle cells. It has often been observed in isolated nuclei, yet cytoplasmic contamination was of course initially regarded as the most plausible origin. Numerous studies on nuclear actin appeared in the 1970s and 1980s, but the picture remained rather muddy. The viewpoint at that time was that actin-shown to move freely between cytoplasm and nucleus-was a mere "thermodynamic wanderer," transiently occupying the nucleus. More recently, evidence has been mounting that actin's presence in the nucleus is not simply governed by the laws of diffusion. The same holds true for the finding of various actin-related proteins in the nucleus, and the case for nuclear myosin, specifically myosin I, is now quite convincing, Moreover, the first intimations of functional roles of nuclear actin are now emerging. Here we examine the overall subject from cell biological and chemical perspectives. The major issue is no longer the presence of actin in the nucleus but rather its supramolecular organization, intranuclear locations, and, of course, functions. These issues interface with recent findings that reveal a surprisingly diverse repertoire of actin conformations and oligomer and polymer forms beyond monomeric G-actin and polymeric F-actin. We present ideas for advancing the nuclear actin field and call for a renewed attack on this major problem in cell biology. (C) 2002 Elsevier Science (USA). All rights reserved. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: Pederson, T (reprint author), Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, 377 Plantat St, Worcester, MA 01605 USA |
Addresses:
1. Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01605 USA
2. Univ Basel, Biozentrum, ME Muller Inst Struct Biol, Basel, Switzerland |
| Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA |
| Subject Category: Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| IDS Number: 627VW |
| ISSN: 1047-8477 |
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