| An actin-myosin complex on actively transcribing genes |
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| Author(s): Fomproix N, Percipalle P |
| Source: EXPERIMENTAL CELL RESEARCH Volume: 294 Issue: 1 Pages: 140-148 Published: MAR 10 2004 |
| Times Cited: 57 References: 25 |
| Abstract: Actin and myosin have been individually implicated in different aspects of gene expression. Here, we show in vivo evidence for a specific nucleolar actin-myosin complex physically associated with both the RNA polymerase I holoenzyme and ribosomal genes. We find that this specific actin-myosin complex is functionally coupled to elongating ribosomal RNA transcripts in living cells. From these observations, we conclude that an actin-based myosin motor is associated with transcribing ribosomal genes in the cell nucleus. These results correlate with an involvement of both actin and myosin in regulating mRNA synthesis and suggest that actin-myosin motors may provide a general mechanism to facilitate elongation of RNA transcripts during transcription of both ribosomal genes and protein-coding genes. (C) 2003 Elsevier Inc. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: Percipalle, P (reprint author), Karolinska Inst, Med Nobel Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden |
Addresses:
1. Karolinska Inst, Med Nobel Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden |
| Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA |
| Subject Category: Oncology; Cell Biology |
| IDS Number: 800KX |
| ISSN: 0014-4827 |
| DOI: 10.1016/j.yexcr.2003.10.028 |