| The molecular mechanics of eukaryotic translation |
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| Author(s): Kapp LD, Lorsch JR |
| Source: ANNUAL REVIEW OF BIOCHEMISTRY Volume: 73 Pages: 657-704 Published: 2004 |
| Times Cited: 152 References: 332 |
| Abstract: Great advances have been made in the past three decades in understanding the molecular mechanics underlying protein synthesis in bacteria, but our understanding of the corresponding events in eukaryotic organisms is only beginning to catch up. In this review we describe the current state of our knowledge and ignorance of the molecular mechanics underlying eukaryotic translation. We discuss the mechanisms conserved across the three kingdoms of life as well as the important divergences that have taken place in the pathway. |
| Document Type: Review |
| Language: English |
| Reprint Address: Kapp, LD (reprint author), Johns Hopkins Univ, Dept Biophys & Biophys Chem, Sch Med, 725 N Wolfe St, Baltimore, MD 21205 USA |
Addresses:
1. Johns Hopkins Univ, Dept Biophys & Biophys Chem, Sch Med, Baltimore, MD 21205 USA |
| Publisher: ANNUAL REVIEWS, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: 845MI |
| ISSN: 0066-4154 |
| DOI: 10.1146/annurev.biochem.73.030403.080419 |