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| Function and regulation of Cullin-RING ubiquitin ligases |
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| Author(s): Petroski MD, Deshaies RJ |
| Source: NATURE REVIEWS MOLECULAR CELL BIOLOGY Volume: 6 Issue: 1 Pages: 9-20 Published: JAN 2005 |
| Times Cited: 382 References: 140 |
| Abstract: Cullin - RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin - RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin - RING ligases, and describe how these enzymes can be characterized by a set of general principles. |
| Document Type: Review |
| Language: English |
| Reprint Address: Petroski, MD (reprint author), CALTECH, Div Biol, 1200 E Calif Blvd, Pasadena, CA 91125 USA |
Addresses:
1. CALTECH, Div Biol, Pasadena, CA 91125 USA
2. CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 884TM |
| ISSN: 1471-0072 |
| DOI: 10.1038/nrm1547 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |