| | |  | | | | Record from Web of Science® | | | | | | |
| Force generation by dynamic microtubulles |
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| Author(s): Dogterom M, Kerssemakers JW, Romet-Lemonne G, Janson ME |
| Source: CURRENT OPINION IN CELL BIOLOGY Volume: 17 Issue: 1 Pages: 67-74 Published: FEB 2005 |
| Times Cited: 57 References: 62 |
| Abstract: The assembly and disassembly of microtubules can generate pushing and pulling forces that, together with motor proteins, contribute to the correct positioning of chromosomes, mitotic spindles and nuclei in cells. In vitro experiments combined with modeling have shed light on the intrinsic capability of dynamic microtubules to generate force, and various observations of positioning processes in cells and model systems have shown how pushing and pulling forces are used in different situations. A sophisticated set of microtubule-end-binding proteins is responsible for steering dynamic microtubules toward their cellular target and regulating the pushing and/or pulling forces that are generated once contact is established. |
| Document Type: Review |
| Language: English |
| Reprint Address: Dogterom, M (reprint author), FOM, Inst Atom & Mol Phys, AMOLF, Kruislaan 407, NL-1098 SJ Amsterdam, Netherlands |
Addresses:
1. FOM, Inst Atom & Mol Phys, AMOLF, NL-1098 SJ Amsterdam, Netherlands
2. Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
3. Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 894YW |
| ISSN: 0955-0674 |
| DOI: 10.1016/j.ceb.2004.12.011 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |