| | |  | | | | Record from Web of Science® | | | | | | |
| Contributions of low molecule number and chromosomal positioning to stochastic gene expression |
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| Author(s): Becskei A, Kaufmann BB, van Oudenaarden A |
| Source: NATURE GENETICS Volume: 37 Issue: 9 Pages: 937-944 Published: SEP 2005 |
| Times Cited: 75 References: 50 |
| Abstract: The presence of low- copy- number regulators and switch- like signal propagation in regulatory networks are expected to increase noise in cellular processes. We developed a noise amplifier that detects fluctuations in the level of low- abundance mRNAs in yeast. The observed fluctuations are not due to the low number of molecules expressed from a gene per se but originate in the random, rare events of gene activation. The frequency of these events and the correlation between stochastic expressions of genes in a single cell depend on the positioning of the genes along the chromosomes. Transcriptional regulators produced by such random expression propagate noise to their target genes. |
| Document Type: Article |
| Language: English |
| Reprint Address: van Oudenaarden, A (reprint author), MIT, Dept Phys, Cambridge, MA 02139 USA |
Addresses:
1. MIT, Dept Phys, Cambridge, MA 02139 USA
2. Harvard Univ, Div Engn & Appl Sci, Cambridge, MA 02138 USA |
| Publisher: NATURE PUBLISHING GROUP, 345 PARK AVENUE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Genetics & Heredity |
| IDS Number: 960LK |
| ISSN: 1061-4036 |
| DOI: 10.1038/ng1616 |
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