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| A brain-specific microRNA regulates dendritic spine development |
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| Author(s): Schratt GM, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M, Greenberg ME |
| Source: NATURE Volume: 439 Issue: 7074 Pages: 283-289 Published: JAN 19 2006 |
| Times Cited: 290 References: 43 |
| Abstract: MicroRNAs are small, non-coding RNAs that control the translation of target messenger RNAs, thereby regulating critical aspects of plant and animal development. In the mammalian nervous system, the spatiotemporal control of mRNA translation has an important role in synaptic development and plasticity. Although a number of microRNAs have been isolated from the mammalian brain, neither the specific microRNAs that regulate synapse function nor their target mRNAs have been identified. Here we show that a brain-specific microRNA, miR-134, is localized to the synaptodendritic compartment of rat hippocampal neurons and negatively regulates the size of dendritic spines-postsynaptic sites of excitatory synaptic transmission. This effect is mediated by miR-134 inhibition of the translation of an mRNA encoding a protein kinase, Limk1, that controls spine development. Exposure of neurons to extracellular stimuli such as brain-derived neurotrophic factor relieves miR-134 inhibition of Limk1 translation and in this way may contribute to synaptic development, maturation and/or plasticity. |
| Document Type: Article |
| Language: English |
| Reprint Address: Greenberg, ME (reprint author), Childrens Hosp, Neurobiol Program, 300 Longwood Ave, Boston, MA 02115 USA |
Addresses:
1. Childrens Hosp, Neurobiol Program, Boston, MA 02115 USA
2. Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
3. Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA
4. Med Univ Vienna, Ctr Brain Res, Div Neuronal Cell Biol, A-1090 Vienna, Austria |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 003LA |
| ISSN: 0028-0836 |
| DOI: 10.1038/nature04367 |
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