| | |  | | | | Record from Web of Science® | | | | | | |
| Building mammalian signalling pathways with RNAi screens |
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| Author(s): Moffat J, Sabatini DM |
| Source: NATURE REVIEWS MOLECULAR CELL BIOLOGY Volume: 7 Issue: 3 Pages: 177-187 Published: MAR 2006 |
| Times Cited: 58 References: 80 |
| Abstract: Technological advances in mammalian systems are providing new tools to identify the molecular components of signalling pathways. Foremost among these tools is the ability to knock down gene function through the use of RNA interference (RNAi). The fact that RNAi can be scaled up for use in high-throughput techniques has motivated the creation of genome-wide RNAi reagents. We are now at the brink of being able to harness the power of RNAi for large-scale functional discovery in mammalian cells. |
| Document Type: Review |
| Language: English |
| Reprint Address: Sabatini, DM (reprint author), Whitehead Inst, 9 Cambridge Ctr, Cambridge, MA 02142 USA |
Addresses:
1. Whitehead Inst, Cambridge, MA 02142 USA
2. MIT, Broad Inst, Cambridge, MA 02139 USA
3. Harvard Univ, Cambridge, MA 02139 USA
4. MIT, Dept Biol, Cambridge, MA 02139 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 015ZP |
| ISSN: 1471-0072 |
| DOI: 10.1038/nrm1860 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |