| | |  | | | | Record from Web of Science® | | | | | | |
| Alternative splicing and RNA selection pressure - evolutionary consequences for eukaryotic genomes |
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| Author(s): Xing Y (Xing, Yi), Lee C (Lee, Christopher) |
| Source: NATURE REVIEWS GENETICS Volume: 7 Issue: 7 Pages: 499-509 Published: JUL 2006 |
| Times Cited: 89 References: 143 |
| Abstract: Genome-wide analyses of alternative splicing have established its nearly ubiquitous role in gene regulation in many organisms. Genome sequencing and comparative genomics have made it possible to look in detail at the evolutionary history of specific alternative exons or splice sites, resulting in a flurry of publications in recent years. Here, we consider how alternative splicing has contributed to the evolution of modern genomes, and discuss constraints on evolution associated with alternative splicing that might have important medical implications. |
| Document Type: Review |
| Language: English |
| Reprint Address: Lee, C (reprint author), Univ Calif Los Angeles, Inst Mol Biol, Ctr Genom & Proteom, Dept Chem & Biochem, Los Angeles, CA 90095 USA |
Addresses:
1. Univ Calif Los Angeles, Inst Mol Biol, Ctr Genom & Proteom, Dept Chem & Biochem, Los Angeles, CA 90095 USA
2. Univ Iowa, Dept Internal Med, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA
3. Stanford Univ, Dept Stat, Stanford, CA 94305 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Genetics & Heredity |
| IDS Number: 054LC |
| ISSN: 1471-0056 |
| DOI: 10.1038/nrg1896 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |