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| Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism |
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| Author(s): Gazzinelli RT (Gazzinelli, Ricardo T.), Denkers EY (Denkers, Eric Y.) |
| Source: NATURE REVIEWS IMMUNOLOGY Volume: 6 Issue: 12 Pages: 895-906 Published: DEC 2006 |
| Times Cited: 56 References: 121 |
| Abstract: Toll-like receptors (TLRs) have emerged as a major receptor family involved in non-self recognition. They have a vital role in triggering innate immunity and orchestrate the acquired immune response during bacterial and viral infection. However, the role of TLRs during infection with protozoan pathogens is less clear. Nevertheless, our understanding of how these parasitic microorganisms engage the host TLR signalling system has now entered a phase of rapid expansion. This Review describes recent insights into how parasitic protozoans are sensed by TLR molecules, and how the TLR system itself can be targeted by these microbial pathogens for their own survival. |
| Document Type: Review |
| Language: English |
| Reprint Address: Gazzinelli, RT (reprint author), Fed Univ Minas Gerais, Dep Biochem & Immunol, BR-31270901 Belo Horizonte, MG Brazil |
Addresses:
1. Fed Univ Minas Gerais, Dep Biochem & Immunol, BR-31270901 Belo Horizonte, MG Brazil
2. Fundacao Oswaldo Cruz, Rene Rachou Res Ctr, Immunopathol Lab, Belo Horizonte, MG Brazil
3. Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA 01655 USA
4. Cornell Univ, Dept Microbiol & Immunol, Coll Vet Med, Ithaca, NY 14853 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Immunology |
| IDS Number: 108MO |
| ISSN: 1474-1733 |
| DOI: 10.1038/nri1978 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |