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| Irreversible cell-cycle transitions are due to systems-level feedback |
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| Author(s): Novak B (Novak, Bela), Tyson JJ (Tyson, John J.), Gyorffy B (Gyorffy, Bela), Csikasz-Nagy A (Csikasz-Nagy, Attila) |
| Source: NATURE CELL BIOLOGY Volume: 9 Issue: 7 Pages: 724-728 Published: JUL 2007 |
| Times Cited: 19 References: 31 |
| Abstract: The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation of certain regulatory proteins. We argue that irreversible transitions in the cell cycle ( or in any other molecular control system) cannot be attributed to a single molecule or reaction, but that they derive from feedback signals in reaction networks. This systems-level view of irreversibility is supported by many experimental observations. |
| Document Type: Article |
| Language: English |
| Reprint Address: Novak, B (reprint author), Univ Oxford, Oxford Ctr Integrat Syst Biol, S Parks Rd, Oxford OX1 3QU, England |
Addresses:
1. Univ Oxford, Oxford Ctr Integrat Syst Biol, Oxford OX1 3QU, England
2. Virginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USA
3. Hungarian Acad Sci, Mol Network Dynam Res Grp, H-1521 Budapest, Hungary
4. Budapest Univ Technol & Econ, H-1521 Budapest, Hungary
5. Univ Trent, Microsoft Res, Ctr Computat & Syst Biol, I-38100 Povo, Trento Italy |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 186EA |
| ISSN: 1465-7392 |
| DOI: 10.1038/ncb0707-724 |
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