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| MALE-MICE DEFECTIVE IN THE DNA MISMATCH REPAIR GENE PMS2 EXHIBIT ABNORMAL CHROMOSOME SYNAPSIS IN MEIOSIS |
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| Author(s): BAKER SM, BRONNER CE, ZHANG L, PLUG AW, ROBATZEK M, WARREN G, ELLIOTT EA, YU JA, ASHLEY T, ARNHEIM N, FLAVELL RA, LISKAY RM |
| Source: CELL Volume: 82 Issue: 2 Pages: 309-319 Published: JUL 28 1995 |
| Times Cited: 386 References: 52 |
| Abstract: Using gene targeting in embryonic stem cells, we have derived mice with a null mutation in a DNA mismatch repair gene homolog, PMS2. We observed microsatellite instability in the male germline, in tail, and in tumor DNA of PMS2-deficient animals. We therefore conclude that PMS2 is involved in DNA mismatch repair in a variety of tissues. PMS2-deficient animals appear prone to sarcomas and lymphomas, PMS2-deficient males are infertile, producing only abnormal spermatozoa. Analysis of axial element and synaptonemal complex formation during prophase of meiosis I indicates abnormalities in chromosome synapsis. These observations suggest links among mismatch repair, genetic recombination, and chromosome synapsis in meiosis. |
| Document Type: Article |
| Language: English |
| Reprint Address: BAKER, SM (reprint author), OREGON HLTH SCI UNIV, DEPT MED & MOLEC GENET, PORTLAND, OR 97201 USA |
Addresses:
1. OREGON HLTH SCI UNIV, DEPT MOLEC MICROBIOL & IMMUNOL, PORTLAND, OR 97201 USA
2. UNIV SO CALIF, PROGRAM MOLEC BIOL, LOS ANGELES, CA 90089 USA
3. YALE UNIV, SCH MED, DEPT GENET, NEW HAVEN, CT 06510 USA
4. YALE UNIV, SCH MED, HOWARD HUGHES MED INST, IMMUNOBIOL SECT, NEW HAVEN, CT 06510 USA
5. AGR UNIV WAGENINGEN, DEPT GENET, 6703 HA WAGENINGEN, NETHERLANDS |
| Publisher: CELL PRESS, 50 CHURCH ST CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: RL760 |
| ISSN: 0092-8674 |
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