| | |  | | | | Record from Web of Science® | | | | | | |
| Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase |
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| Author(s): Hales KG, Fuller MT |
| Source: CELL Volume: 90 Issue: 1 Pages: 121-129 Published: JUL 11 1997 |
| Times Cited: 222 References: 56 |
| Abstract: The Drosophila melanogaster fuzzy onions (fzo) gene encodes the first known protein mediator of mitochondrial fusion. During Drosophila spermatogenesis, mitochondria in early postmeiotic spermatids aggregate, fuse, and elongate beside the growing flagellar axoneme. fro mutant males are defective in this developmentally regulated mitochondrial fusion and are sterile. fro encodes a large, novel, predicted transmembrane GTPase that becomes detectable on spermatid mitochondria late in meiosis II, just prior to fusion, and disappears soon after fusion is complete. Missense mutations that alter conserved residues required for GTP binding in other GTPases inhibit the fusogenic activity of Fzo in vivo but do not affect its localization. Fzo has homologs of unknown function in mammals, nematodes, and yeast. |
| Document Type: Article |
| Language: English |
Addresses:
1. STANFORD UNIV, SCH MED, DEPT GENET, STANFORD, CA 94305 USA
2. STANFORD UNIV, SCH MED, DEPT DEV BIOL, STANFORD, CA 94305 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: XL362 |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |