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| Heterogeneous distribution of the unusual phospholipid semilysobisphosphatidic acid through the Golgi complex |
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| Author(s): Cluett EB, Kuismanen E, Machamer CE |
| Source: MOLECULAR BIOLOGY OF THE CELL Volume: 8 Issue: 11 Pages: 2233-2240 Published: NOV 1997 |
| Times Cited: 23 References: 47 |
| Abstract: To investigate the distribution of lipids through the Golgi complex, we analyzed the envelopes of several viruses that assemble in different subcompartments of the Golgi, as well as subcellular fractions. Our results indicate that each Golgi subcompartment has a distinct phospholipid composition due mainly to differences in the relative amounts of semilysobisphosphatidic acid (SLBPA), sphingomyelin, phosphatidylserine, and phosphatidylinositol. Interestingly, SLBPA is enriched in the adjacent Golgi networks compared with the Golgi stack, and this enrichment varies with cell type. The heterogeneous distribution of SLBPA through the Golgi complex suggests it may play an important role in the structure and/or function of this organelle. |
| Document Type: Article |
| Language: English |
| Reprint Address: Cluett, EB (reprint author), JOHNS HOPKINS UNIV, SCH MED, DEPT CELL BIOL & ANAT, BALTIMORE, MD 21205 USA |
Addresses:
1. UNIV HELSINKI, DEPT BIOSCI, HELSINKI, FINLAND |
| Publisher: AMER SOC CELL BIOLOGY, PUBL OFFICE, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 |
| Subject Category: Cell Biology |
| IDS Number: YE027 |
| ISSN: 1059-1524 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |